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WordNet-Online 
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Noun bother has 2 senses
- fuss, trouble, bother, hassle - an angry disturbance; "he didn't want to make a fuss"; "they had labor trouble"; "a spot of bother"
 
--1 is a kind of perturbation, disturbance 
 - annoyance, bother, botheration, pain, infliction, pain in the neck, pain in the ass - something or someone that causes trouble; a source of unhappiness; "washing dishes was a nuisance before we got a dish washer"; "a bit of a bother"; "he's not a friend, he's an infliction"
 
--2 is a kind of negative stimulus 
--2 has particulars: nuisance; irritant, thorn; plague
   
Verb bother has 6 senses
- trouble oneself, trouble, bother, inconvenience oneself - take the trouble to do something; concern oneself; "He did not trouble to call his mother on her birthday"; "Don't bother, please"
 
--1 is one way to strive, reach, strain 
Sample sentences: 
 Something ----s 
 Somebody ----s to INFINITIVE 
 - annoy, rag, get to, bother, get at, irritate, rile, nark, nettle, gravel, vex, chafe, devil - cause annoyance in; disturb, especially by minor irritations; "Mosquitoes buzzing in my ear really bothers me"; "It irritates me that she never closes the door after she leaves"
 
--2 is one way to displease 
Sample sentences: 
 Somebody ----s somebody 
 Something ----s somebody 
 - trouble, put out, inconvenience, disoblige, discommode, incommode, bother - to cause inconvenience or discomfort to; "Sorry to trouble you, but..."
 
--3 is one way to affect, impact, bear upon, bear on, touch on, touch 
Sample sentences: 
 Somebody ----s somebody 
 Something ----s somebody 
 - bother - intrude or enter uninvited; "Don't bother the professor while she is grading term papers"
 
--4 is one way to intrude, irrupt 
Sample sentence: 
 Somebody ----s somebody 
- bother - make nervous or agitated; "The mere thought of her bothered him and made his heart beat faster"
 
--5 is one way to agitate, rouse, turn on, charge, commove, excite, charge up 
Sample sentences: 
The bad news will bother him 
The performance is likely to bother Sue 
 - bother - make confused or perplexed or puzzled
 
--6 is one way to confuse, flurry, disconcert, put off 
Sample sentence: 
The bad news will bother him 
   
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