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WordNet-Online 
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Verb tranquilize has 2 senses
- calm, calm down, quiet, tranquilize, tranquillize, tranquillise, quieten, lull, still - make calm or still; "quiet the dragons of worry and fear"
 
--1 is one way to comfort, soothe, console, solace 
Sample sentence: 
Sam cannot tranquilize Sue  
 - sedate, calm, tranquilize, tranquillize, tranquillise - cause to be calm or quiet as by administering a sedative to; "The patient must be sedated before the operation"
 
--2 is one way to affect 
Sample sentence: 
 Somebody ----s somebody 
  
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