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Definitions from WordNet

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Homogentisic Acid

Definition

Homogentisic acid is an organic compound with the chemical formula C₈H₈O₄. It is derived from tyrosine metabolism and is an intermediate in the degradation of phenylalanine and tyrosine. Homogentisic acid is primarily known for its role in the development of alkaptonuria, a rare genetic disorder.

Senses

1. Medical Sense

In a medical context, homogentisic acid refers to the excess accumulation of the acid in the body due to a deficiency of homogentisate 1,2-dioxygenase enzyme. This condition is responsible for alkaptonuria, which causes dark urine, joint and connective tissue problems, and other health complications.

Example: The doctor ordered a homogentisic acid test to confirm the presence of alkaptonuria in the patient.

2. Biological Sense

Homogentisic acid serves as a crucial intermediate in the biochemical pathway of phenylalanine and tyrosine metabolism. It plays a role in the degradation of these amino acids.

Example: The enzyme homogentisic acid oxidase catalyzes the conversion of homogentisic acid into another compound in the degradation pathway.

Related Products

Find related products on Amazon:

• Homogentisic Acid Supplements
• Alkaptonuria Management Books
• Tyrosine Metabolism Products