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Definitions from WordNet

Definitions from the Web

HMG-CoA Reductase

Description:

HMG-CoA reductase is an enzyme that plays a vital role in the cholesterol synthesis pathway. It catalyzes the conversion of HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) to mevalonate, which is a key step in the production of cholesterol in the body. Inhibition of HMG-CoA reductase is the primary mechanism of action of statin drugs, which are commonly prescribed to lower cholesterol levels.

Sample Sentences:

• The statin medication works by blocking the activity of HMG-CoA reductase, thus reducing the production of cholesterol.
• HMG-CoA reductase is considered an essential target for cholesterol-lowering therapies.
• The expression of HMG-CoA reductase is tightly regulated by various factors in the body.

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